GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs59948050 | 1 | rs59948050 | chr1:15915157 | SLC25A34 | chr1:16062809-16067885:+ | -0.18 | -3.8 | 0.000162 | Morning vs. evening chronotype |
| THCA | cis | rs7216064 | 1 | rs59950564 | chr17:65860859 | C17orf58 | chr17:65987218-65989765:- | 0.2 | 3.95 | 8.87E-5 | Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma |
| THCA | cis | rs2129782 | 1 | rs59951423 | chr8:89372154 | MMP16 | chr8:89049462-89339717:- | 0.31 | 4.88 | 1.48E-6 | Electrodermal activity |
| THCA | cis | rs2076028 | 1 | rs5995610 | chr22:39064681 | JOSD1 | chr22:39081549-39096459:- | -0.15 | -4 | 7.32E-5 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5995610 | chr22:39064681 | TOMM22 | chr22:39077954-39080763:+ | -0.17 | -3.65 | 0.000291 | Resting heart rate |
| THCA | cis | rs1930961 | 1 | rs5996946 | chr22:25875988 | CRYBB2 | chr22:25615612-25627836:+ | 0.84 | 12.8 | 1.88E-32 | Bipolar disorder with mood-incongruent psychosis |
| THCA | cis | rs7714584 | 1 | rs59980321 | chr5:150241813 | LOC134466 | chr5:150310000-150326146:- | 0.42 | 5.86 | 8.57E-9 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs59980321 | chr5:150241813 | ZNF300 | chr5:150273964-150284391:- | 0.16 | 3.46 | 0.000586 | Crohn's disease |
| THCA | cis | rs41997 | 1 | rs59989824 | chr7:118175322 | ANKRD7 | chr7:117864712-117882782:+ | 0.25 | 4.11 | 4.74E-5 | Response to platinum-based chemotherapy in non-small-cell lung cancer |
| THCA | cis | rs35123781 | 1 | rs599946 | chr5:139057461 | DNAJC18 | chr5:138747381-138775139:- | 0.16 | 3.66 | 0.000278 | Schizophrenia |
| THCA | cis | rs726288 | 1 | rs60000965 | chr10:81729165 | LOC219347 | chr10:81805991-81838949:- | 0.51 | 5.21 | 2.88E-7 | Rheumatoid arthritis |
| THCA | cis | rs2076028 | 1 | rs6001173 | chr22:39015302 | JOSD1 | chr22:39081549-39096459:- | -0.13 | -3.49 | 0.000522 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs6001173 | chr22:39015302 | LOC646851 | chr22:38974125-39052634:- | 0.15 | 3.91 | 0.000106 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs6001173 | chr22:39015302 | TOMM22 | chr22:39077954-39080763:+ | -0.17 | -3.76 | 0.00019 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs6001175 | chr22:39018334 | JOSD1 | chr22:39081549-39096459:- | -0.14 | -3.7 | 0.000242 | Resting heart rate |